temp files

I am getting a crapload of temp folders on my secondary file of type
\RANDOM_#\wcu\dotNetFramework\dotNetFX20
The folders have 10 .msp files in them

I cannot delete the folders at all. I can't dtermine with procesex who
has the files open. I now have 7 of these folders on my drive. how do
I get rid of them, or kill the process that is creating these?

Peter