Site-to-site VPN between two PIX501"s

I'm going to be setting up my first site-to-site vpn connection between

two PIX501's. My understanding is that it may be as easy as running
the vpn wizard in the pdm on each pix. But, I have a feeling that it
might not be that easy. Can anyone give me any insight as to what I
might encounter and should be prepared for? Best practices?